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CALCITONIN GENE-RELATED PEPTIDE RECEPTOR (CGRP-R) ANTAGONIST
Ajovy (fremanezumab-vfrm) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for the preventive treatment of migraine in adults and episodic migraine in children ages 6 to 17 who weigh 45 kilograms or more.
These insights are based on 926 comments about Ajovy from MyMigraineTeam members. These are the experiences of a small number of individuals and are not meant to be medical advice.
Benefits:
Considerations:
Ajovy works by blocking calcitonin gene-related peptide (CGRP), a pain-signaling protein linked to migraine. In people with migraine, blocking the effects of CGRP may help reduce signals involved in migraine attacks, although the exact way Ajovy helps is not fully known.
Doctors prescribe Ajovy when adults need preventive treatment for migraine, or when children ages 6 to 17 who weigh 45 kilograms or more need preventive treatment for episodic migraine. Ajovy is given as an injection under the skin, typically once a month or once every three months.
With proper training, Ajovy can be given at home. Injections can be given from a prefilled autoinjector or prefilled syringe under the skin in the abdomen, back of the upper arms, front of the thighs, or upper back.
In adults, the recommended dose of Ajovy for migraine is 225 milligrams once monthly or 675 milligrams once every three months. The 675-milligram dose is administered as three consecutive injections of 225 milligrams each.
In children ages 6 to 17 who weigh 45 kilograms or more, the recommended dose is 225 milligrams once monthly.
This information is based on the prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
These insights are based on 926 comments about Ajovy from MyMigraineTeam members.
Members who use Ajovy often say that staying in close contact with a neurologist or headache specialist, keeping track of how long each dose seems to last, and being patient about results can help set expectations. Many also mention reporting side effects or unusual reactions promptly.
Be patient, because improvement can take time for some.
“It took the second treatment to work so don’t get discouraged if your first 28 days don’t show much improvement.”
Keep track of when the dose seems to wear off.
“Ajovy injections have helped some but seems to wear off in the last week to week and a half.”
Tell your doctor about side effects or unusual reactions.
“I’m contacting Ajovy nurse and neurologist today, as I know if this is what I have to put up with every month no way am I using Ajovy.”
Talk to your doctor about the dosing schedule that fits you.
“My doctor told me that I could take my Ajovy injections once a quarter by taking three at once.”
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In clinical trials of Ajovy in adults and children, the most common side effect, occurring in about 43 percent to 45 percent of people, was:
Ajovy can cause serious side effects that may require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
Teva Pharmaceuticals USA, the manufacturer of Ajovy, offers the Ajovy Savings Card. Eligible people with commercial insurance may pay as little as $15 out of pocket for Ajovy. This offer is not available for people eligible for Medicare, Medicaid, or any other public payer coverage.
To learn more, visit the Ajovy savings website, or call 844-309-5477.
Tell your doctor if you have any allergies to fremanezumab-vfrm or any ingredients in Ajovy. Do not take Ajovy if you have had a serious allergic reaction to fremanezumab-vfrm or any of its ingredients.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, and supplements.
Before you use Ajovy, tell your healthcare provider if you:
If a dose of Ajovy is missed, take it as soon as possible. After that, you can restart your schedule based on the date of your last dose.
If you are pregnant, planning to become pregnant, or breastfeeding while taking Ajovy, talk with your doctor about the risks and benefits. If you are pregnant, you can enroll in the Ajovy pregnancy registry by calling 833-927-2605 or visiting the Teva Migraine Pregnancy Registry.
These answers are fact-checked by our editorial staff.
How effective is Ajovy?
In adult clinical studies for migraine prevention, Ajovy helped reduce monthly migraine days. When taken either monthly or quarterly over a three-month period, the average number of migraine days per month was reduced by at least half in about 38 percent to 48 percent of people with migraine, depending on the medication regimen.
In pediatric clinical studies, children and adolescents taking Ajovy saw a significant improvement in the number of migraine days per month during a three-month study period. When taken monthly, about 47 percent of children and adolescents with episodic migraine had the average number of monthly migraine days reduced by at least half, compared with 27 percent of those on placebo (an inactive treatment).
How long does Ajovy take to work for migraine prevention?
In clinical studies, some people showed improvement by the first month after starting Ajovy treatment for migraine prevention.
On MyMigraineTeam, people share their experiences with migraine, get advice, and find support from others who understand.
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