Overview
Depakote is approved by the U.S. Food and Drug Administration (FDA) for the prophylaxis (prevention) of migraine attacks in adults. Depakote is also known by its drug name, divalproex sodium.

Depakote is an anti-seizure drug. Scientists believe it works by increasing the levels of a neurotransmitter (chemical messenger) called gamma-aminobutyric acid (GABA) in the brain, which helps to stabilize nerve activity and prevent migraine headaches.

How do I take it?
Prescribing information states that Depakote is taken by mouth in the form of delayed-release tablets. For migraine prevention, the recommended starting dose is taken twice daily and may be increased as needed. The tablets should be swallowed whole and not crushed or chewed. Depakote should be taken exactly as prescribed by a healthcare provider.

Side effects
Common side effects of Depakote include abdominal pain, alopecia (hair loss), asthenia (weakness), diarrhea, diplopia (double vision), dizziness, headache, infection, insomnia, nausea, somnolence (sleepiness), thrombocytopenia (low platelet count), tremor, and vomiting.

Rare but serious side effects may include hepatotoxicity (liver damage), pancreatitis (inflammation of the pancreas), fetal risk (birth defects and decreased IQ if used during pregnancy), suicidal thoughts or behaviors, bleeding and other hematopoietic (blood-related) disorders, hyperammonemia and hyperammonemic encephalopathy (high ammonia levels in the blood causing brain dysfunction), hypothermia (low body temperature), severe skin reactions, and angioedema (swelling under the skin).

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Label: Depakote- Divalproex Sodium Tablet, Delayed Release — DailyMed