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CALCITONIN GENE-RELATED PEPTIDE RECEPTOR ANTAGONIST
Nurtec ODT (rimegepant) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat migraine with or without aura in adults and to prevent episodic migraine in adults.
These insights are based on 74 comments about Nurtec ODT from MyMigraineTeam members. These are the experiences of a small number of people and are not meant to be medical advice.
Benefits:
Considerations:
Nurtec ODT is a calcitonin gene-related peptide (CGRP) receptor antagonist. It works by blocking the CGRP receptor, which is involved in migraine.
Doctors prescribe Nurtec ODT when adults need treatment for a migraine attack, with or without aura. Nurtec ODT is also used for preventive treatment of episodic migraine in adults.
Nurtec ODT is an orally disintegrating tablet taken by mouth. It is typically taken as needed for a migraine attack or every other day for preventive treatment. Nurtec ODT can be taken with or without food.
The recommended dose of Nurtec ODT for migraine attacks is 75 milligrams taken by mouth as needed. The recommended dose of Nurtec ODT for preventing migraine is 75 milligrams taken by mouth every other day.
A healthcare provider may advise you not to take more than one dose in 24 hours. The safety of using more than 18 doses in a 30-day period has not been established.
This information is based on the prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
These insights are based on 74 comments about Nurtec ODT from MyMigraineTeam members.
Members who use Nurtec ODT often say that timing, consistency, and follow-up with a doctor can make a big difference in how the medication fits into their migraine plan. Many also mention tracking triggers, especially when migraine attacks are frequent or hard to control.
Take Nurtec ODT early for acute attacks.
“Yes, the key is to take it as it is ‘starting’ to tense up such as your neck or the back of your skull, shoulders, etc.”
Talk to your doctor about whether every-other-day dosing fits your plan.
“I now take Nurtec ODT every other day. It reduced the frequency and the intensity.”
Keep a migraine log and watch for triggers.
“I was told to keep a log of when I got a migraine and what I took for it.”
Let your doctor know if Nurtec ODT is not helping enough.
“Yes, I’m on Nurtec ODT now, and it doesn’t work for me half the time.”
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In clinical studies of Nurtec ODT, the most common side effects occurred in about 2 percent of people. They include:
Nurtec ODT can cause serious side effects that may require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
Pfizer, the manufacturer of Nurtec ODT, offers the Nurtec ODT Savings Card. Eligible people with commercial insurance may pay as little as $0.
To learn more, visit the Nurtec ODT Savings and Support page, or call 866-222-4183.
Tell your doctor if you have any allergies to rimegepant or any ingredients in Nurtec ODT. Do not take Nurtec ODT if you have had a serious allergic reaction to rimegepant or any of its ingredients.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, and supplements.
Before you take Nurtec ODT, tell your healthcare provider about all your medical conditions, including if you:
If you are pregnant, planning to become pregnant, or breastfeeding while taking Nurtec ODT, talk with your doctor about the risks and benefits. There is a pregnancy exposure registry for people who take Nurtec ODT during pregnancy.
To register, call 877-366-0324, or visit the Nurtec ODT pregnancy registry. Very small amounts of Nurtec ODT pass into breast milk, but it is not known whether Nurtec ODT affects a breastfed baby.
These answers are fact-checked by our editorial staff.
How effective is Nurtec ODT?
In a study of adults treating a migraine attack, about 21 percent of people taking Nurtec ODT were pain-free at two hours, compared with about 11 percent taking placebo (an inactive treatment). Also at two hours, about 35 percent had relief from their most bothersome symptom, such as light sensitivity, sound sensitivity, or nausea, compared with about 27 percent with placebo.
In a separate study of preventive treatment for episodic migraine, people taking Nurtec ODT every other day experienced a significant reduction in monthly migraine days at 12 weeks. Almost 50 percent of people saw their days with moderate to severe headache pain intensity cut in half, compared with 41.5 percent with placebo.
How long does Nurtec ODT take to work for migraine attacks?
After taking Nurtec ODT for a migraine attack, about 37 percent of people experienced pain relief within one hour, and about 59 percent experienced pain relief within two hours. For some people, pain relief lasted up to 48 hours.
Can Nurtec ODT be used with other medicines for migraine?
Some medicines can affect how Nurtec ODT works in your body. Your doctor will let you know what is safe and what should be avoided.
Do not take Nurtec ODT with strong CYP3A4 inhibitors or with strong or moderate CYP3A inducers. If you take Nurtec ODT with a moderate CYP3A4 inhibitor or a potent P-gp inhibitor, do not take another dose within 48 hours.
On MyMigraineTeam, people share their experiences with migraine, get advice, and find support from others who understand.
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