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CALCITONIN GENE-RELATED PEPTIDE RECEPTOR ANTAGONIST
Qulipta (atogepant) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to help prevent migraine in adults.
These insights are based on 275 comments about Qulipta from MyMigraineTeam members. These are the experiences of a small number of individuals and are not meant to be medical advice.
Benefits:
Considerations:
Qulipta is a type of medication called a calcitonin gene-related peptide (CGRP) receptor antagonist. It works by blocking CGRP receptors. CGRP is a pain-signaling protein linked to migraine.
In migraine, this helps reduce signals that can trigger or sustain attacks. Doctors prescribe Qulipta when adults need help preventing migraine.
Qulipta is a daily migraine medication given as a tablet by mouth, typically once daily. It can be taken with or without food.
For episodic migraine, the recommended dose of Qulipta is 10 milligrams, 30 milligrams, or 60 milligrams taken once daily. For chronic migraine, the recommended dose is 60 milligrams taken once daily.
Your doctor may change your dose if you take certain other medicines, including some medicines that affect CYP3A4 or OATP, or if you have severe kidney problems or are on dialysis.
This information is based on the prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
These insights are based on 275 comments about Qulipta from MyMigraineTeam members.
Members who use Qulipta often say it works best as part of a broader migraine plan, not as a guaranteed fix on its own. Many also stress the importance of staying in touch with a neurologist or headache specialist, watching for side effects, and asking about cost-saving programs when affordability becomes a barrier.
Ask your doctor about combining Qulipta with other migraine treatments.
“I am taking Qulipta, a new migraine medication, and I think the combination of Botox and Qulipta are an amazing combination. I have been migraine free for two weeks, and that is a record for me because I had daily migraines.”
Tell your doctor about side effects that show up after starting Qulipta.
“Dr had started me on Qulipta, but it was giving me nausea and vomiting, so I stopped taking it.”
Let your doctor know if cost or insurance is a problem.
“Now the manufacturer is sending three-month supplies of each med for 12 months for $0 copay, and then I can renew for another 12 months.”
Connect with others who understand life with migraine. Join MyMigraineTeam for free.
In clinical studies of Qulipta for the preventive treatment of migraine in adults, the most common side effects occurred in about 4 percent to 9 percent of people. These include:
Qulipta can cause serious side effects that may require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
AbbVie, the manufacturer of Qulipta, offers the Qulipta Patient Savings Program. Eligible people with commercial insurance may pay as little as $0 a month.
The Qulipta Patient Savings Program also offers Qulipta shipped directly to your door if you experience an insurance delay or denial. To learn more, visit the Qulipta Patient Savings Program or call 855-785-4782.
Tell your doctor if you have any allergies to atogepant or any ingredients in Qulipta. Do not take Qulipta if you have had a serious allergic reaction to atogepant or any of its ingredients.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.
Before taking Qulipta, tell your doctor about all of your medical conditions, including if you:
If you are pregnant, planning to become pregnant, or breastfeeding while taking Qulipta, talk with your doctor about the risks and benefits. There is a pregnancy exposure registry for people who take Qulipta during pregnancy.
To register, visit the EMPRESS Pregnancy Registry or call 833-277-0206.
These answers are fact-checked by our editorial staff.
How effective is Qulipta?
In 12-week studies of adults with episodic migraine, people taking Qulipta had about 3.6 to 4.2 fewer migraine days each month. People taking placebo (an inactive treatment) had about 2.5 to 2.8 fewer migraine days each month.
Depending on the dose, 56 percent to 61 percent of people taking Qulipta had their monthly migraine days reduced by at least 50 percent. In the placebo group, 29 percent of people had their migraine days reduced by at least half.
In a 12-week study of adults with chronic migraine, people taking Qulipta 60 milligrams once daily had 6.9 fewer monthly migraine days. People taking placebo had 5.1 fewer monthly migraine days.
In that study, 41 percent of people taking Qulipta had their monthly migraine days reduced by at least 50 percent, compared with 26 percent of people taking placebo.
How long does Qulipta take to work for migraine?
After taking Qulipta, peak blood levels are reached in about one to two hours. In clinical studies, migraine prevention results were measured over a 12-week treatment period.
The study results do not say exactly when people may start to notice improvement.
Can Qulipta cause constipation with migraine treatment?
Yes. Constipation was one of the most common side effects seen in clinical studies of Qulipta.
Constipation happened in:
In comparison, constipation happened in 2 percent of people taking placebo.
On MyMigraineTeam, people share their experiences with migraine, get advice, and find support from others who understand.
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