Treximet (Sumatriptan/Naproxen) for Migraine | MyMigraineTeam

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Treximet is a prescription drug approved by the Food and Drug Administration (FDA) to treat acute migraine headaches with or without aura in people 12 and older. Treximet is a combination drug composed of Sumatriptan and Naproxen.

Sumatriptan is a triptan. Triptans are believed to work by constricting blood vessels and reducing inflammation. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). NSAIDs help reduce fever, pain, and inflammation. Naproxen is believed to work by inhibiting the production of chemicals that promote inflammation and blood clot formation in the body.

How do I take it?
Treximet is generally taken once or twice a day.

Treximet comes in the tablet form.

Side effects
The FDA-approved label for Treximet lists common side effects including drowsiness, dizziness, dry mouth, hot flashes, “pins and needles” tingling sensation, muscle tightness, nausea, upset stomach, and sensations of tightness, pressure, or discomfort in the neck, jaw, throat, or chest.

Rare but serious side effects listed for Treximet include stroke, cerebral hemorrhage (bleeding), serotonin syndrome, medication overuse headache, thrombotic events (blood clots), liver or kidney damage, high blood pressure, heart failure, and ischemia (insufficient blood supply) to the heart, spleen, or gastrointestinal system.

For answers to frequently asked questions about exposure to Sumatriptan during pregnancy and breastfeeding, visit the experts at

For more details about this treatment, visit:
Treximet – Pernix Therapeutics

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