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CALCITONIN GENE-RELATED PEPTIDE RECEPTOR (CGRP-R) ANTAGONIST
Ubrelvy (ubrogepant) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat migraine with or without aura in adults.
These insights are based on 796 comments about Ubrelvy from MyMigraineTeam members. These are the experiences of a small number of people and are not meant to be medical advice.
Benefits:
Considerations:
Ubrelvy is a type of medication called a calcitonin gene-related peptide receptor antagonist. It works by blocking a pain-signaling pathway linked to migraine. In migraine, this helps reduce signals in the body that can drive head pain and other symptoms during an attack.
Doctors prescribe Ubrelvy when an adult needs treatment for a migraine attack, with or without aura.
Ubrelvy comes as a tablet taken by mouth, typically when a migraine attack starts. If needed, a second dose may be taken at least two hours after the first dose.
The recommended dose of Ubrelvy for migraine is 50 milligrams or 100 milligrams taken by mouth, with or without food. If needed, a second dose may be taken at least two hours after the first dose. The maximum dose in 24 hours is 200 milligrams.
It is unclear if taking Ubrelvy for more than eight migraine attacks in 30 days is safe.
This information is based on the prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
These insights are based on 796 comments about Ubrelvy from MyMigraineTeam members.
Members who use Ubrelvy often say timing, side effects, and communication with a specialist matter most. Many describe using it as an acute treatment at the first sign of a migraine, while also keeping their doctor informed about side effects, drug interactions, and how well it is working over time.
Take it early and ask your doctor about timing.
“I have learned by experience and through communication with my neurologist to take Ubrelvy if I feel a regular headache coming on but also if I feel any symptoms of a migraine or symptoms leading to a future one coming on like black floaters in my vision as well as bursts of sparks of light to take it as well.”
Keep track of sleepiness or nausea.
“It does make me sleep for several hours and when I wake up my headache is usually just a dull ache.”
Tell your doctor or pharmacist about other medicines, and be mindful of drug interactions.
“Always read the info and talk to your pharmacist because they often know more about drug interactions more quickly.”
Let your doctor know if Ubrelvy stops helping enough.
“I have taken Ubrelvy as a rescue med for about six months. At first it worked really well and now as time goes on, it’s starting to work less.”
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In clinical trials of Ubrelvy for the acute treatment of migraine with or without aura in adults, the most common side effects occurred in about 2 percent to 4 percent of people. They include:
Ubrelvy can cause serious side effects that may require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
AbbVie, the manufacturer of Ubrelvy, offers the Ubrelvy Complete Savings Card. Eligible people with commercial insurance may pay as little as $0 per monthly prescription fill.
This copay assistance program is not available to people receiving prescription reimbursement under federal, state, or government-funded insurance programs, such as Medicare, Medicaid, TRICARE, Department of Defense, or Veterans Affairs programs.
To learn more, visit the Ubrelvy Complete page, or call 844-482-7358.
Tell your doctor if you have any allergies to ubrogepant or any ingredients in Ubrelvy. Do not take Ubrelvy if you have had a serious allergic reaction to ubrogepant or any ingredient in Ubrelvy.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, and supplements.
Do not take Ubrelvy if you are taking medicines known as strong CYP3A4 inhibitors, such as ketoconazole, clarithromycin, or itraconazole. Ask your healthcare provider if you are not sure if you are taking any of these medicines.
Before you take Ubrelvy, tell your healthcare provider about all of your medical conditions, including if you:
If you are pregnant, planning to become pregnant, or breastfeeding while taking Ubrelvy, talk with your doctor about the risks and benefits. If you become pregnant while taking Ubrelvy, you can enroll in a pregnancy exposure registry by calling 833-277-0206 or visiting the Empress Pregnancy Registry website. Very small amounts of Ubrelvy pass into breast milk.
Talk with your healthcare provider if you plan to breastfeed.
These answers are fact-checked by our editorial staff.
How effective is Ubrelvy?
In clinical studies, Ubrelvy helped more people become pain-free after two hours than placebo (an inactive treatment). In one study, about 19 percent of people taking 50 milligrams and about 21 percent taking 100 milligrams were pain-free at two hours, compared with about 12 percent taking placebo. Ubrelvy also improved the most bothersome migraine symptom at two hours, such as light sensitivity, sound sensitivity, or nausea.
How long does Ubrelvy take to work for migraine?
It is unknown how quickly Ubrelvy starts to work for migraine attacks, but studies showed that pain relief is possible two hours after taking Ubrelvy.
Can Ubrelvy be used with other medicines for migraine?
Ubrelvy can interact with some medicines, so it is important to tell your doctor about all prescription drugs, over-the-counter medicines, and herbal products you use. Do not take Ubrelvy with strong CYP3A4 inhibitors, such as:
Some other medicines and products may require you to avoid taking Ubrelvy or change the dose, including:
On MyMigraineTeam, people share their experiences with migraine, get advice, and find support from others who understand.
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