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CALCITONIN GENE-RELATED PEPTIDE (CGRP) ANTAGONISTS
Vyepti (eptinezumab-jjmr) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to prevent migraine in adults.
These insights are based on 297 comments about Vyepti from MyMigraineTeam members. These are the experiences of a small number of individuals and are not meant to be medical advice.
Vyepti is a type of medication called a monoclonal antibody that works by blocking calcitonin gene-related peptide, or CGRP, a protein involved in migraine. During a migraine, this helps reduce signals in the body that can trigger migraine attacks.
Doctors prescribe Vyepti when an adult needs treatment to help prevent migraine attacks.
Vyepti is given as an intravenous infusion, typically once every three months.
The recommended dose of Vyepti for migraine is 100 milligrams given by intravenous infusion every three months. Some people may benefit from 300 milligrams given by intravenous infusion every three months.
This information is based on the prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
These insights are based on 297 comments about Vyepti from MyMigraineTeam members.Members who use Vyepti often say it can take time to see how well it works, and that results vary from person to person. Many also suggest staying in close touch with a neurologist about timing, dose, side effects, cost, and whether Vyepti works best as part of a broader migraine plan.
Be patient. Improvement takes more time for some than others.
“I have been doing Vyepti for seven infusions now. I didn’t feel the benefit until my third infusion.”
Talk to your doctor if the effects don’t seem to last the full three months between doses.
“They had to change the dosage from the 100 to the 300. It works better. It gives relief but doesn’t eliminate the migraines.”
Plan ahead for insurance and infusion scheduling.
“Last few times I’ve had to call them in advance even before the doctor does, just so they get the medication there.”
Connect with others who understand life with migraine. Join MyMigraineTeam for free.
In clinical trials of Vyepti for the preventive treatment of migraine in adults, the most common side effects occurred in about 1 percent to 8 percent of people. These include:
Vyepti can cause serious side effects that may require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction to Vyepti.
Lundbeck Seattle BioPharmaceuticals, the manufacturer of Vyepti, offers the Vyepti Connect Copay Assistance Program. Eligible people with commercial insurance may pay as little as $0 per infusion every three months.
The Vyepti Connect Copay Assistance Program includes up to $200 per treatment toward administration out-of-pocket costs. This offer is not available for people enrolled in Medicare, Medicaid, or any other government healthcare program.
To learn more, visit the Vyepti financial assistance page or call 833-4-VYEPTI (833-489-3784).
Tell your doctor if you have any allergies to Vyepti or any ingredients in Vyepti.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, and supplements.
Tell your healthcare provider if you have high blood pressure or if you have circulation problems in your fingers or toes, which relates to Raynaud’s phenomenon.
Do not take Vyepti if you have had a serious allergic reaction to Vyepti or any of its ingredients.
If you are pregnant, planning to become pregnant, or breastfeeding while taking Vyepti, talk with your doctor about the risks and benefits. There is a pregnancy exposure registry that monitors pregnancy outcomes in those who are exposed to Vyepti during pregnancy.
To learn more, call 855-810-8549 or visit the Vyepti Pregnancy Registry.
These answers are fact-checked by our editorial staff.
How effective is Vyepti?
In studies of adults using Vyepti every three months to prevent migraine, people with episodic migraine had about 3.9 fewer monthly migraine days with 100 milligrams and 4.3 fewer monthly migraine days with 300 milligrams, compared with 3.2 fewer days with placebo (an inactive treatment) over months 1 through 3. In chronic migraine, monthly migraine days decreased by 7.7 days with 100 milligrams and 8.2 days with 300 milligrams, compared with 5.6 days with placebo over months 1 through 3.
In one study of people who had a migraine on the day of infusion, 23.5 percent were pain-free at two hours after a 100-milligram dose, compared with 12 percent with placebo.
How long does Vyepti take to work for migraine?
In clinical studies for migraine prevention, results were measured over months 1 through 3 after treatment. In a separate study of people who had a migraine during the infusion visit, 23.5 percent were pain-free at two hours after a 100-milligram dose, compared with 12 percent with placebo.
Study information does not say that everyone will notice benefit on the same timeline.
Can Vyepti be used with other medicines for migraine?
Tell your healthcare provider about all the medicines you take. This includes prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.
The prescribing information says interactions are unlikely with medicines that use certain liver enzymes called cytochrome P450 enzymes. The prescribing information also says that taking Vyepti with a single dose of sumatriptan did not significantly affect either medicine.
No other medicines should be mixed with Vyepti or given through the same infusion set.
On MyMigraineTeam, people share their experiences with migraine, get advice, and find support from others who understand.
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