I took 10 mg Nortryptiline for 3 years. Didn't do a thing. I went to a migraine specialist and he said it was too low dose, he adjusted it to 40 mg. Didn't do a thing.
Then I read an article from The National Headache Foundation (great source of info!) that mentioned that Amitryptaline works better for some migraine sufferers.
I asked my neuro to switch me to that. BINGO! It's the first thing I took that had any effect on reducing the frequency of my chronic migraines.
I now take 30-50 mg a day. 50 works better but causes major dry mouth for me, so I try to keep it to 30 mg as much as possible which considerably reduces that effect. You may not have that issue though.
September 6
Nortriptyline (you may see it spelled "nortriptyline") is a tricyclic antidepressant that's commonly prescribed off-label to help *prevent* migraines. It's a well-established option in migraine management.
Here's the key thing to understand about preventive medications like nortriptyline: Preventive treatments are designed Show Full Answer
Nortriptyline (you may see it spelled "nortriptyline") is a tricyclic antidepressant that's commonly prescribed off-label to help *prevent* migraines. It's a well-established option in migraine management.
Here's the key thing to understand about preventive medications like nortriptyline: Preventive treatments are designed to reduce the frequency and severity of migraine attacks — not necessarily eliminate them completely. Think of it as turning down the volume rather than switching it off entirely.
A few other important things to know:
- At 10 mg, this is considered a low dose — doctors often start low and adjust over time
- Tricyclic antidepressants like nortriptyline can take up to four weeks to reach their peak effectiveness
- Side effects can include dry mouth, dizziness, drowsiness, weight gain, and nausea
It's really worth keeping an open conversation with your neurologist about how well it's working. Tracking how often migraines occur and how severe they are can help guide any dose adjustments or treatment changes needed.
September 2