MyMigraineTeam

Switching from Aimovig to Ajovy makes a lot of sense given the side effects experienced. Both belong to the same class of CGRP monoclonal antibody drugs, but they work slightly differently — Ajovy targets the CGRP protein itself, while Aimovig blocks the CGRP receptor. This difference can mean a better tolerance for some Show Full Answer

Switching from Aimovig to Ajovy makes a lot of sense given the side effects experienced. Both belong to the same class of CGRP monoclonal antibody drugs, but they work slightly differently — Ajovy targets the CGRP protein itself, while Aimovig blocks the CGRP receptor. This difference can mean a better tolerance for some people.

Ajovy's common side effects include:
- Injection site pain
- Fatigue
- Constipation
- Itching

It's worth flagging the constipation concern with a doctor before starting, since that was already an issue with Aimovig. Since Imitrex (sumatriptan) has been working well, that's a great anchor in the treatment plan. It's a well-established triptan for both chronic migraine and migraine with aura.

One thing to be mindful of — using triptans too frequently can increase the risk of medication overuse headache, so it's worth discussing a safe usage schedule with the doctor.

Having an open conversation with the new doctor about what has and hasn't worked over 45 years is really important. A specialist who understands the full history can help find the right combination of rescue and preventive treatments.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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